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Molecular Medicine
Introduction. Oxidative stress and mitochondrial dysfunction are observed in virtually any disease associated with premature aging. Signaling molecules produced by mitochondria can act as specific targets for the action of pharmacological agents in order to re…
Introduction. Activation of glial cells by lipopolysaccharide leads to the release of proinflammatory cytokines and the development of neuroinflammation, which, in turn, affects the processes of neuro- and synaptogenesis. However, the specific mechanisms of ne…
Introduction. The worldwide trend towards green technologies has increased interest in the development and use of natural, highly-efficiency and inexpensive plant antioxidants to replace existing synthetic ones. Purpose of the study. study of the composition o…
The aim of the study was to study the effect of chemical immobilization of yeast cell wall glycoproteins on their ability to activate cytokine production by human peripheral blood cells. Methods. A comparative analysis of the immunomodulatory activity of yeast…
Introduction. Viral infections induce cellular and humoral immunity that provide virus elimination. Extracellular presentation of antigens of formaldehyde-inactivated vaccines causes mainly humoral immune response with risk of persistent infection. The aim of …
The aim is the comparative analysis of saliva concentration of sirtuins, in middle age and elderly people without cardiovascular pathology (CP) and with coronary heart disease (CHD). Methods. Saliva was obtained from healthy donors (73 persons without CP, «nor…
Introduction. Mitochondria are one of the most important cellular organelles that provide cells with energy, take part in cellular renewal and the implementation of endogenous mechanisms of cellular immunity. The study of the structural and functional organiza…
Introduction. It was shown, that L-amino acids can take part in regulation of the main physiological processes. Various combination of L-amino acids takin into account of its biological activity can apply for peptide drugs synthesis for target therapy of socia…
Introduction. Statins are a group of effective lipid – lowering medications. A common side effect of long-term statin use is myopathy. The mechanism of its development is not fully understood at the molecular level, making it difficult to find effective drugs …
The aim was to correlate the content of cytokines/chemokines in the oral fluid of patients undergoing orthodontic treatment with the results of laser correlation (LC) spectroscopy in order to develop approaches to prenosological diagnostics. Methods. Oropharyn…