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Molecular Medicine
Introduction. Developing of chronic emotional stress reduces adaptive capabilities of people ill with diabetes mellitus causing the condition of decompensation with significant elevation of counterinsular hormones production and further progressive metabolic d…
Introduction. The human microbiota is part of the «human-microbiome» system and is actively involved in developing various pathological responses and conditions in the body. It is currently essential to study the pathogenesis of ulcerative colitis (UC), a poly…
Introduction. The molecular mechanisms of the development of tumor pathology of the thyroid gland are associated with the activation of angiogenesis and the development of hypoxia, which contributes to the proliferation, invasion, and progression of the diseas…
Introduction. Thyroid cancer (TC) is the most prevalent cancer among malignant neoplasms of the organs of the endocrine system. Cytological categories Bethesda III–V of TC are considered to be the most difficult for making a diagnosis. Molecular genetic tests …
Introduction. The delay of the adverse events by the use of drugs is an actual medicine task. The cytostatics inhibiting cellular proliferation, are using in a clinic for the hindering tumor development. Thus, the adverse events occur due to the damage of heal…
Introduction. The quantitative determination and isotyping of autoantibodies to a clinically significant protein – glutathione-S-transferase (GST) in blood serum samples is relevant for monitoring and predicting the dynamics of autoimmune processes. The aim of…
Introduction. Revealing the relationship between the severity of oxidative stress and the activity of cathepsins in tissues (plasma and blood cells) readily available for the diagnosis of Alzheimer’s disease can be useful for understanding the pathogenesis of …
Introduction. The development of neurodegeneration in Alzheimer’s disease is inextricably linked with oxidative stress, a marker of which is oxidative protein modification. In the tissues of the brain, cerebrospinal fluid and plasma in Alzheimer’s disease, an …
Introduction. The single-nucleotide polymorphisms rs75555045 and rs12904699 were found in the own genome-wide allelotyping as possible new molecular genetic markers of sudden cardiac death (SCD). The results obtained in such studies require verification in the…
Introduction. Continuous glucose monitoring (СGM) is currently one of the most promising methods for controlling type 1 diabetes (T1D). Flash monitoring is the most relevant and promising direction in diabetology, which allows to monitor the level of glycemia …