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Molecular Medicine
Introduction. Clinical observations have revealed that the treatment of schizophrenia with the use of chlorpromazine (CPZ) impairs cognitive processes. Whether it is possible to eliminate these side effects of CPZ? The aim of the study. The aim of our study wa…
Introduction. Oxidative processes in the pathogenesis of chronic cardiovascular diseases play a key role. Oxidative stress causes the damage of many cellular components, including lipids and proteins. Oxidative modification of low-density lipoprotein triggers …
Introduction. Ambient air pollution is important worldwide problem. Numerous studies have found associations between air pollution and respiratory diseases, cardiovascular diseases, diabetes, and infant mortality. Children are more susceptible to the air pollu…
Introduction. The ACTA2 gene encodes α-actin in aortic smooth muscle cells, and its mutations may cause thoracic aortic aneurysms. Analysis of ACTA2 polymorphism can be used in a complex risk assessment of non-familial thoracic aortic aneurysms. The aim of the…
Aim. To investigate the possible association between XRCC1 Arg399Gln and p53 Arg72Pro polymorphism and the risk of breast cancer (BC) risk in Kyrgyz women. Methods. The XRCC1 Arg399Gln and p53 Arg72Pro genotypes were determined with the use of the polymerase c…
Introduction. Tumor necrosis factor (TNF) plays a central role in the development of inflammatory and neoplastic processes. In the TNF gene promoter region there are -308(g/a) and -238(G/A) polymorphisms with different influence on the level of expression of T…
Introduction. Currently, in the pathogenesis of various diseases have been intensively studied the structure and function of innate immune receptors, a special role played by a Toll-like receptors (TLR). In the recent literature there are no comprehensive stud…
Introduction. Sex hormones are known to influence on synthesis of growth factors in breast and uterus tumors, but their correlation in polyneoplasias is poorly studied. The aim of the study. The analyze local steroidogenesis, synthesis of growth factors and th…
Introduction. Papillary thyroid cancer (PTC) is the most common malignancy of the endocrine system. As the most frequent genetic alteration BRAF V600E mutation in PTC leads to changes in the activity of intracellular signaling pathways. As a result, expression…
Introduction. Alternative splicing of telomerase catalytic subunit hTERT (human Telomerase Reverse Transcriptase) regulates the telomerase activity. The increased expression of non-active spliced hTERT results in inhibition of telomerase. However, very little …