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Molecular Medicine
Found: 848
Venous thromboembolism (VTE) is a frequent complication associated with increased mortality in cancer patients. The basic role in pathogenesis of thrombotic complication in cancer patients is played by changes in the hemostatic system caused by the tumor itsel…
Serum κ- and λ- free light chains and their ratio were measured in 126 patients (23-80 years old) with monoclonal gammopathies and 60 normal individuals (25-82 years old). The free light chains (FLCs) assay was performed using the FreeliteTM test-system (The B…
Associations between matrix metalloproteinase (MMP) 2, 7, 9, tissue MMP inhibitor TIMP-1 and plasminogen activation system components (uPA, tPA and PAI-1) plasma and/or tumor levels in colorectal cancer (CRC) patients were evaluated in order to reveal their po…
Diffuse large B-cell lymphoma is the most common lymphoma worldwide. Both morphologically and prognostically it represents a diverse spectrum of disease. Non-Hodgkin lymphoma of bone comprises approximately 7% of malignant bone tumors, 5% of extranodal lymphom…
Protein expression of CRABP I (Сellular Retinoic Acid Binding Protein I) was investigated by immunohistochemical analysis in pancreatic neuroendocrine tumors. Relationship of CRABPI expression to clinical features, cell proliferation activity level and metasta…
The immunohistochemical expression of MMP-2 and MMP-3 in carcinomas of the stomach, differed by product MUC1, 2, 5AС, 6 and CD10 has been investigated. In mixed carcinomas immunophenotypic variant parameters of studied MMP expression were significantly higher …
The main goal of the project was to study the heightened tolerance of the resistant breast cancer cells to hypoxia. Two in vitro cultured breast cancer cell lines, the estrogen-dependent MCF-7 cells and the resistant ER-negative HBL-100 cells were used in the …
In the paper there are presented results of the study of the mechanisms of accumulation of the radiocolloid preparation in white blood cells. The study included an assessment of the effect of conditions of blood sampling (the diameter of the needle) and incuba…
Assessment of the effectiveness of thrombolytic and anticoagulation therapies was performed in 92 patients with pulmonary tromboembolism (PTE), aged from 22 to 88 years (average age is 59,3±13,9 years). In accordance with the diagnostics algorithm of PTE, acce…
With the purpose to determine the content of apoptotic lymphocytes of venous blood in norm and pathology there were examined 40 primary donors of blood, 14 patients with closed abdominal trauma complicated by acute blood loss of at least 30% of circulating blo…
Electrochemical method of antioxidants level determination in biological media was developed. The comparison of the blood serum redox potential and antioxidant activity for practically health people (n=31) was carried out. The effect of added antioxidants and …
Spiral computed tomography (CT) with contrast enhancement allows both to study changes of densitometric parameters in different phases of research and to get information about the features of vascularization in the focal formation of liver, which underlies the…
aryngeal and laryngopharyngeal cancer response to neoadjuvant chemotherapy as well as to investigate the feasibility of 199Tl-chloride for visualization of primary and recurrent laryngeal tumors. Materials and Methods: The study included 60 patients with stage…
Retrospective analysis of data of histological and ultrasound examination of 199 fragments of arterial wall of internal carotid artery obtained during reconstructive operations was conducted. A retrospective analysis of ultrasound data and histological examina…
A recent literature review presents main approaches of cell fluorescence study in various fields of biology and medicine, including molecular medicine, problems of vital stained cell analysis and the prospect of fluorescent microscopy application.
Ductal adenocarcinoma is the most common type of pancreatic tumors that is notable for its highly aggressive phenotype, difficulties in diagnosis establishing, exceptionally unfavorable prognosis and resistance to standard methods of therapy . The development …
Publications devoted to the role of various representatives of matrix metalloproteinases (MMPs) family and their tissue inhibitors in ovarian cancer in differential diagnostics, prognosis and in the development of new treatment modalities are critically analyz…
Preclinical experimental study of toxic and allergenic properties of new pharmaceutical composition of diindolylmethane was carried on in various doses. It was established that tested drug refers to toxicity class V (almost non-toxic pharmaceutical substance) …
Last successful results in target therapy of cancer were achieved with different tyrosine kinases inhibitors (TKI). Target therapy of non-small cell lung cancer (NSCLC) with EGFR inhibitors gefitinib and erlotinib is effective only in patients with somatic mut…
The review is devoted to the role of some signaling molecules produced by neuroendocrine and immune cells of the gastrointestinal tract (GIT) in the pathogenesis of the diseases of the digestive system. Special attention is paid to the key signaling molecules …