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Molecular Medicine
Found: 109
Introduction. Skeletal involvement is a frequent and troublesome complication of breast malignant tumors. The accurate diagnosis of bone metastasis and well-timed prescription of the antiresorptive therapy are essential for reducing both severity and mortality…
Introduction. The features of pathogenesis of main tumors of the female reproductive system are determined by the impact of estrogen on target tissues. In this connection there appears the need to study the regulation of estrogen and progesterone receptors in …
Introduction. Interactions of exposed on the tumor cell surface or circulating in the bloodstream molecules MICA with activating receptor NKG2D play an important role in the regulation of antitumor immune response. Accumulation of soluble MICA compromises NKG2…
Targeted delivery of anticancer drugs is a new direction aimed to delivery preparations capable of enhancing selectivity of action of drugs owing to the use of vector molecules. Targeted drug delivery system is the construction that includes three components: …
Introduction. Matrix metalloproteinase (MMP) – a family of extracellular zinc-containing proteases. There are currently 25 known MMP. Increased activity of MMP observed in some physiological processes – during the follicular phase of the menstrual cycle and du…
Introduction.Uveal melanoma (UM) is one of the most frequent intraocular tumors. Mutations in new oncogenes GNAQ and GNA11 are found in more than 50% of UM. GNAQ gene and its homologue GNA11 are coding the alpha subunit of heterotrimeric G-protein with GTPase …
Introduction. Insulin-like growth factors (IGFs) signaling system plays a key role in development and progression of various malignant tumors, and its components may be considered as prospective diagnostic and prognostic markers and potential objects of target…
The content of VEGF and some components of plasminogen activation system (uPA, PAI-1 and tPA) was determined by enzyme immunoassay methods in the tumors from 121 endometrial cancer patients and in 18 samples of endometrial hyperplasia. Concentrations of uPA an…
RANK/RANKL/OPG system – is a key element in bone homeostasis. In this review we depict the basic principles of functioning of this system and known genetical anomalies affecting its components. Also we describe a number of pathological states associated with d…
In the article a review of recent data on the molecular nature of neuroendocrine tumors of the pancreas (pancreatic NETs) is presented. The genetic basis of inherited syndromes associated with the development of pancreatic NETs: multiple endocrine neoplasia ty…
Early diagnosis of ovarian cancer (OC) remains to be the actual problem in modern oncology due to the high mortality rate, asymptomatic course of the disease in the early stages and its aggressiveness. The aim was to study the genetic polymorphism of pathogene…
Immunohistochemical and molecular biological characterization of Ewing’s sarcoma family tumors is proposed. Immunophenotypical heterogeneity is shown to be noted, besides genome defects found in tumours.
The paper presents the results of our own investigation of abnormal methylation of tumor suppressor genes RASSF1A, P16, CDH1, LAMC3, DAPK in tumors and non-tumor tissues obtained from 64 patients with superficial bladder cancer. The purpose of the research is …
Ethiology and pathogenesis of bone tumors presenting a rare group of oncological diseases, are not fully understood. We have studied 6 single nucleotide polymorphisms rs7921 (GH1), rs7956547(IGF1), rs3761243(GNRH2), rs11737764(FGF2), rs6599400(FGFR3), rs169091…
Venous thromboembolism (VTE) is a frequent complication associated with increased mortality in cancer patients. The basic role in pathogenesis of thrombotic complication in cancer patients is played by changes in the hemostatic system caused by the tumor itsel…
Associations between matrix metalloproteinase (MMP) 2, 7, 9, tissue MMP inhibitor TIMP-1 and plasminogen activation system components (uPA, tPA and PAI-1) plasma and/or tumor levels in colorectal cancer (CRC) patients were evaluated in order to reveal their po…
Diffuse large B-cell lymphoma is the most common lymphoma worldwide. Both morphologically and prognostically it represents a diverse spectrum of disease. Non-Hodgkin lymphoma of bone comprises approximately 7% of malignant bone tumors, 5% of extranodal lymphom…
Protein expression of CRABP I (Сellular Retinoic Acid Binding Protein I) was investigated by immunohistochemical analysis in pancreatic neuroendocrine tumors. Relationship of CRABPI expression to clinical features, cell proliferation activity level and metasta…
The immunohistochemical expression of MMP-2 and MMP-3 in carcinomas of the stomach, differed by product MUC1, 2, 5AС, 6 and CD10 has been investigated. In mixed carcinomas immunophenotypic variant parameters of studied MMP expression were significantly higher …
Spiral computed tomography (CT) with contrast enhancement allows both to study changes of densitometric parameters in different phases of research and to get information about the features of vascularization in the focal formation of liver, which underlies the…